论文部分内容阅读
本实验观察了给予大剂量维生素 D_3的大鼠全血和心肌组织中的 GSH-Px 的活性、钙含量及心脏病理形态学的变化。结果表明:大剂量维生素 D_3可使大鼠全血 GSH-Px 活性降低,心肌中钙含量明显增高,心肌细胞发生变性及点灶状坏死。预先给予亚硒酸钠可提高 GSH-Px 的活性,降低心肌中钙含量,减轻心肌坏死程度。本实验提示:大剂量维生素 D_3所致心肌损害与自由基脂质过氧化、心肌细胞内钙超负荷密切相关。
In this study, we observed the changes of GSH-Px activity, calcium content and cardiac pathomorphology in whole blood and myocardial tissue of rats given high-dose vitamin D_3. The results showed that high dose of vitamin D 3 could decrease the activity of GSH-Px in rat whole blood, the content of calcium in myocardium was significantly increased, the degeneration of cardiomyocytes and focal necrosis were observed. Pretreatment with sodium selenite can increase the activity of GSH-Px, reduce the content of calcium in myocardium and reduce the degree of myocardial necrosis. This experiment suggests that: high-dose vitamin D 3-induced myocardial damage and lipid peroxidation of free radicals, myocardial calcium overload are closely related.