论文部分内容阅读
目的探讨血管内皮生长因子(VEGF)、微血管密度(MVD)及Ki-67在宫颈鳞状细胞癌中的表达及意义。方法采用免疫组织化学S-P法测定45例宫颈鳞癌组织和10例正常宫颈组织中VEGF、Ki-67和F8的表达。结果宫颈鳞癌中VEGF的表达阳性率为77.78%,Ki-67标记指数(Ki-67LI)和MVD分别为12.7±4.1和37±10,VEGF表达水平与肿瘤恶性程度、Ki-67 LI和MVD计数呈正相关。结论VEGF有促进肿瘤细胞增殖及血管生成的作用,联合检测VEGF、Ki-67和F8可作为病理诊断的补充,对患者预后判断和治疗方案的选择有重要的参考价值。
Objective To investigate the expression and significance of vascular endothelial growth factor (VEGF), microvessel density (MVD) and Ki-67 in cervical squamous cell carcinoma. Methods The expressions of VEGF, Ki-67 and F8 in 45 cases of cervical squamous cell carcinoma and 10 cases of normal cervical tissue were detected by immunohistochemical S-P method. Results The positive rate of VEGF expression in cervical squamous cell carcinoma was 77.78%, the Ki-67 labeling index (Ki-67LI) and MVD were 12.7 ± 4.1 and 37 ± 10, respectively. The expression of VEGF correlated with tumor malignancy, Ki- The counts were positively correlated. Conclusions VEGF can promote the proliferation and angiogenesis of tumor cells. Combined detection of VEGF, Ki-67 and F8 can be used as a supplement to pathological diagnosis. It has important reference value for judging patients prognosis and selecting treatment options.