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目的探讨全视网膜光凝术联合药物治疗糖尿病视网膜病变对患者血清VEGF及Cys C水平的影响。方法将212例我院就诊的糖尿病视网膜病变的患者随机分为研究组和对照组各106例。对照组采取单纯药物治疗,研究组在对照组基础上加用全视网膜光凝术治疗,2组治疗前后分别检测并比较血清VEGF及Cys C水平。结果2组治疗前血清VEGF及Cys C水平差异无统计学意义(P>0.05),治疗后2组VEGF、Cys C水平均明显低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论全视网膜光凝术联合药物治疗糖尿病视网膜病变较单纯药物治疗能更有效的降低血清VEGF及Cys C水平。
Objective To investigate the effect of panretinal photocoagulation combined with drugs on diabetic patients with retinopathy and serum VEGF and Cys C levels. Methods A total of 212 patients with diabetic retinopathy treated in our hospital were randomly divided into study group and control group with 106 cases each. The control group was treated with pure drug. The study group was treated with panretinal photocoagulation on the basis of the control group. The levels of serum VEGF and Cys C were detected and compared before and after treatment in both groups. Results There was no significant difference in serum VEGF and Cys C between the two groups before treatment (P> 0.05). The levels of VEGF and Cys C in the two groups after treatment were significantly lower than those before treatment, and the difference between the two groups was statistically significant Significance (P <0.05). Conclusion Total retinal photocoagulation combined with drug treatment of diabetic retinopathy is more effective than simple drug therapy to reduce serum VEGF and Cys C levels.