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目的:从4例碘对比剂过敏高危患者的药学干预情况探讨对于高危患者预防给药的必要性。方法:临床药师协助医师对所在病区集中出现的3例碘对比剂过敏反应进行处理,并通过查阅相关指南和文献,制定了碘对比剂过敏反应发生后处理及高危患者的预防方案,同时进行临床宣教,且在之后需行造影检查的既往发生过对比剂过敏反应的患者给予了预防给药措施。结果:3例发生过敏反应的患者经过处理后症状好转出院,1例既往发生过对比剂过敏反应的患者经过预防给药后,本次检查未发生过敏反应。结论:对比剂过敏的药物预防方案包括糖皮质激素和抗组胺药物组合,可口服或注射的多种方式,对于既往发生过碘对比剂过敏情况的患者临床医生可以此作为参考。
OBJECTIVE: To explore the need for prophylactic administration in high-risk patients from four pharmaceutical interventions in high-risk patients with iodine contrast hypersensitivity. Methods: The clinical pharmacists assisted the physicians to deal with the allergic reaction of iodine contrast agent in 3 cases. The relevant guidelines and literature were reviewed, and the prophylaxis of post-treatment of allergic reaction to iodine contrast agent and the prevention of high-risk patients were made. Clinical mission, and in the subsequent need for angiography had occurred in the past, contrast agent allergic patients given preventive measures. Results: Three patients with anaphylaxis were treated and their symptoms improved. One patient with previous allergic reaction had no allergic reaction after prophylaxis. CONCLUSIONS: The drug-control regimen for contrast-induced allergy includes a combination of glucocorticoid and antihistamine drugs that can be administered orally or in a variety of forms and can be used by clinicians as a reference for patients who have had an allergic reaction to iodinated contrast agents.