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为了观察中药补肾固髓片对实验性变态反应性脑脊髓炎(EAE)动物的发病及病理组织形态的影响,本实验采用兔脊髓匀浆和完全福氏佐剂制成的抗原-佐剂乳化液诱导豚鼠EAE动物模型,应用中药补肾固髓片作为治疗药物,以醋酸泼尼松作为对照药物,经口灌药。结果,大剂量补肾固髓片能明显抑制EAE发病,减轻其病情,对脑和脊髓的炎症反应和脱髓鞘改变亦有明显抑制作用,与对照药醋酸泼尼松组比较差异无显著性。中剂量补肾固髓片在某些方面有效,小剂量组则无明显疗效。表明大剂量补肾固髓片能抑制EAE动物发病,并能明显改善其病情及病理改变,提示中药补肾固髓片有临床研究和应用价值;而且其治疗作用与给药剂量相关。
In order to observe the effect of Bushengujie Tablet on the pathogenesis and pathological morphology of experimental allergic encephalomyelitis (EAE) animals, this experiment used an antigen-adjuvant emulsification made from rabbit spinal cord homogenate and complete Freund’s adjuvant. Liquid-induced guinea pig EAE animal model, the use of Chinese medicine Bushen solid-core tablets as a therapeutic drug, prednisone acetate as a control drug, oral administration. As a result, large doses of Bushen Gudu Tablets significantly inhibited the pathogenesis of EAE, reduced its condition, and significantly inhibited inflammatory and demyelinating changes in the brain and spinal cord. There was no significant difference compared with the control group prednisone acetate. The middle-dose Bushen Gucheng tablet is effective in some aspects, while the low-dose group has no significant effect. It showed that high-dose Bushengudu can inhibit the pathogenesis of EAE animal, and can significantly improve the condition and pathological changes, suggesting that there is clinical research and application value of Bushengujie tablet; and its therapeutic effect is related to the dose.