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（目的）观察低剂量DDP＋VDS为主的联合化疗对晚期乳腺癌的治疗效果。（方法）22例晚期乳腺癌，采用CMVP方案9例，CFW方案5例，CAVP方案8例，一个疗程后评价疗效及毒性反应。（结果）总有效率68．2％。其中CMVP667％，CFVP60．0％，CAVP75．0％。初治有效率66．7％，复治有效率57．9％，两者相比差异无显著性（P＞0．05）。主要毒副反应为胃肠反应、骨髓抑制、脱发、静脉炎；末梢神经炎及肾毒性轻。（结论）以低剂量DDP＋VDS为主的联合化疗方案治疗晚期乳腺癌毒副反应轻、患者易接受、疗效高于以DDP为主或VDS为主的联合化疗，两者联合可作为治疗晚期乳腺癌的一线方案。
(Objective) To observe the effect of low DDP plus VDS combined chemotherapy on advanced breast cancer. (Methods) Twenty-two cases of advanced breast cancer were treated with CMVP regimen in 9 cases, CFW regimen in 5 cases, and CAVP regimen in 8 cases. Efficacy and toxicity were evaluated after one course of treatment. (Results) The total effective rate was 68.2%. Of which CMVP667%, CFVP60.0%, CAVP75.0%. The initial treatment rate was 66.7%, and the retreatment rate was 57.9%. There was no significant difference between the two groups (P>0.05). The main toxicities were gastrointestinal reactions, myelosuppression, alopecia, phlebitis; peripheral neuritis and nephrotoxicity. (Conclusion) The combination of low DDP and VDS-based chemotherapy for the treatment of advanced breast cancer has mild side effects and is easily accepted by patients. The efficacy is higher than that of DDP or VDS. The combination of the two can be used as a treatment for advanced breast cancer. The first-line program.