【摘 要】
：
Six novel monacolin analogs,monacolins V1-V6 (1-6),together with seven known ones (7-13),were isolated from the ethyl acetate extract of red yeast rice.Their structures and absolute configurations were determined by spectroscopic methods,especially 2D NMR
【机 构】
：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia
论文部分内容阅读
Six novel monacolin analogs,monacolins V1-V6 (1-6),together with seven known ones (7-13),were isolated from the ethyl acetate extract of red yeast rice.Their structures and absolute configurations were determined by spectroscopic methods,especially 2D NMR (1H-1HCOSY,HSQC,HMBC,and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation.Monacolins V2 (2) and V3 (3) represent the first examples of monacolins with 3-hydroxybutyrate substitute.The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.
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