【摘 要】
：
Seven new isoquinoline alkaloids,9-(2\'-formyl-5\',6\'-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine (1),9-(2\'-formyl-5\',6\'-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine (2),3-methoxy-2\'-formyl oxohemandalin (3),(-)-9-(
【机 构】
：
Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chi
论文部分内容阅读
Seven new isoquinoline alkaloids,9-(2\'-formyl-5\',6\'-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine (1),9-(2\'-formyl-5\',6\'-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine (2),3-methoxy-2\'-formyl oxohemandalin (3),(-)-9-(2\'-methoxycarbonyl-5\',6\'-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine (4),(-)-2\'-methoxycarbonyl thaliadin (5),(-)-9-(2\'-methoxyethyl-5\',6\'-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine (6),(-)-3-methoxy hydroxyhemandalinol (7),together with six known isoquinoline alkaloids (8-13) were isolated from the roots of Thalictrumfoetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells (GSC-3# and GSC-18#) with IC50 values ranging from 2.36 to 5.37 μg·mL-1.
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