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目的利用相干光断层扫描仪深度增强成像(EDI-OCT)模式分析慢性丙型肝炎干扰素治疗前后脉络膜厚度的变化。设计回顾性病例系列。研究对象北京地坛医院干扰素治疗的平均年龄(43.7±10.5)岁的HCV患者11例(22眼)。方法在接受干扰素治疗前及治疗后3个月行矫正视力、眼压、裂隙灯显微镜、散瞳间接检眼镜、眼底彩色照相及用海德堡SPECTRALIS-OCT深度增强成像模式检查。主要指标黄斑中心凹下脉络膜厚度(SFCT)。结果 11例患者中6例9眼出现干扰素相关性视网膜病变。22眼治疗前SFCT(317.6±78.8)μm和治疗后(280.1±77.1)μm有明显统计学差异(P=0.000)。出现视网膜病变的眼(9眼)与未出现视网膜病变的眼(13眼)干扰素治疗后SFCT分别为(320.5±82.4)μm和(252.1±61.7)μm(P=0.053)。结论慢性丙型肝炎患者干扰素治疗后SFCT有变薄的趋势。
Objective To analyze the changes of choroidal thickness before and after treatment with interferon-alpha in chronic hepatitis C by using the coherence tomography depth enhanced imaging (EDI-OCT) mode. Design retrospective case series. Study subjects The average age (43.7 ± 10.5) years of HCV patients treated with interferon in Beijing Ditan Hospital was 11 (22 eyes). Methods The corrected visual acuity, intraocular pressure, slit lamp microscope, mydriatic indirect ophthalmoscope, fundus color photography and depth enhanced imaging modalities with Heidelberg SPECTRALIS-OCT were performed before interferon treatment and 3 months after treatment. The main indicators of macular subfoveal choroidal thickness (SFCT). Results Of the 11 patients, 6 of 9 patients had interferon-related retinopathy. 22 eyes before treatment, SFCT (317.6 ± 78.8) μm and after treatment (280.1 ± 77.1) μm, there was a statistically significant difference (P = 0.000). SFCT was (320.5 ± 82.4) μm and (252.1 ± 61.7) μm (P = 0.053), respectively, in patients with and without retinopathy (13 eyes). Conclusion The trend of SFCT thinning in patients with chronic hepatitis C after interferon treatment.