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To evaluate the relationship between the α2-Heremans Schmidt glycoprotein (A HSG) gene polymorphism and endometriosis. Case-control study. Department of Obs tetrics and Gynecology, Seoul National University Hospital, Korea. Seventy-nine women with endometriosis and 105 women without endometriosis. Determination of AHSG gene polymorphism. Prevalence of AHSG genotypes or alleles. The allele freq uencies of AHSG 1 and AHSG 2 were found to be 0.69 and 0.31, respectively. The p roportion of noncarriers of the AHSG 2 allele was significantly higher in women with endometriosis than in women without (55.7%vs. 39.0%). Women not carrying the AHSG 2 allele were found to have twice the risk of endometriosis than those carrying at least one copy of this allele. No significant difference was noted i n the distribution of the AHSG alleles or AHSG genotypes between early stage end ometriosis and late stage endometriosis. Endometriosis is associated with the AH SG gene polymorphism in Korean women.
To evaluate the relationship between the α2-Heremans Schmidt glycoprotein (HSG) gene polymorphism and endometriosis. Case-control study. Department of Obstrics and Gynecology, Seoul National University Hospital, Korea. Seventy-nine women with endometriosis and 105 women without endometriosis . The determination of AHSG gene polymorphism. Prevalence of AHSG genotypes or alleles. The allele freq uencies of AHSG 1 and AHSG 2 were found to be 0.69 and 0.31, respectively. The p roportion of noncarriers of the AHSG 2 allele was significantly higher in women with Women not carrying the AHSG 2 allele were found to have twice the risk of endometriosis than those carrying at least one copy of this allele. No significant difference was observed in the distribution of the AHSG alleles or AHSG genotypes between early stage end ometriosis and late stage endometriosis. Endometriosis is associated with the AH SG gene polymorphism in Korean women.