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目的 :应用静息态功能磁共振(resting-state functional magnetic resonance imaging,rs-f MRI)的分析方法 ,从神经影像学的角度研究正常学龄期儿童脑网络发育的特征。方法:3组学龄期儿童(7~8岁16例、9~10岁18例、11~12岁15例)分别进行rs-f MRI扫描,采用度中心度(degree centrality,DC)作为测量指标。结果:差异明显的脑区包括左侧颞下回(F=77.309,P<0.001)、左侧中扣带回(F=10.821,P<0.001);两脑区7~8岁组DC值低于9~10岁组和11~12岁组,差异均有统计学意义(P<0.05);9~10岁组和11~12岁组DC值比较,差异无统计学意义(P>0.05)。结论:随着年龄增长,学龄期儿童三维空间相关的脑网络发育逐渐完善;9~10岁可能是学龄期儿童三维空间相关脑网络发育的关键期。
OBJECTIVE: To study the characteristics of brain network development in normal school-aged children from the perspective of neuroimaging using the method of resting-state functional magnetic resonance imaging (rs-f MRI). Methods: Three groups of school-age children (16 in 7 to 8 years, 18 in 9 to 10 years and 15 in 11 to 12 years) were scanned with rs-f MRI respectively, and the degree centrality (DC) was used as the measurement index . Results: The brain regions with obvious difference included the left inferior temporal gyrus (F = 77.309, P <0.001), the left cingulate gyrus (F = 10.821, P <0.001) The difference was statistically significant (P <0.05) between 9 to 10 years old group and 11 to 12 years old group (P <0.05). There was no significant difference in DC value between 9 to 10 years old group and 11 to 12 years old group (P> 0.05) . CONCLUSION: With age, the development of brain network related to three-dimensional space in school-age children gradually improves. The age of 9 to 10 years may be the key period for the development of brain-related three-dimensional space network in school-age children.