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目的：分析原发性输卵管腺癌的ＥＲ、ＰＲ及ｐ５３蛋白的表达，研究其与该肿瘤的临床分期、病理分级及患者预后的关系。方法：材料选自２０份原发性输卵管腺癌及１０份正常输卵管组织的存档石蜡包埋标本，采用免疫组化法检测。结果：在２０份原发性输卵管癌标本中，ＥＲ、ＰＲ的阳性表达率分别为２５％和１５％，稍高于正常输卵管组的１０％，但差异无显著性（Ｐ＞０．０５）；ｐ５３蛋白在癌症组的阳性表达率为４０％，对照组则无１例阳性表达，差异有显著性（Ｐ＜０．０５）；ｐ５３蛋白在晚期、分化差及预后不良的输卵管癌病例中的表达呈上升趋势，但未达到统计学意义（Ｐ＞０．０５）；对侧输卵管炎症的存在与ｐ５３蛋白的阳性表达呈负相关（Ｐ＜０．０５）。结论：在原发性输卵管癌中，ＥＲ、ＰＲ有一定程度的表达，但均较低；ｐ５３基因的突变可能参与了该肿瘤的发生，并可作为综合判断其恶性程度及患者预后的指标之一。
OBJECTIVE: To analyze the expression of ER, PR and p53 protein in primary fallopian tube adenocarcinoma, and to study its relationship with clinical stage, pathological grade and prognosis. METHODS: Materials were selected from archived paraffin-embedded specimens of 20 primary salpingo-oesophageal carcinomas and 10 normal salpingitis tissues and detected by immunohistochemistry. Results: The positive rates of ER and PR were 25% and 15% respectively in 20 primary esophageal squamous cell carcinomas, which was slightly higher than that of normal oviduct group (P> 0.05) ; The positive rate of p53 protein in cancer group was 40%, while in the control group, there was no one positive expression (P <0.05); p53 protein in patients with advanced, poorly differentiated and poor prognosis of tubal carcinoma (P> 0.05). The contralateral fallopian tube inflammation was negatively correlated with the positive expression of p53 protein (P <0.05). CONCLUSIONS: ER and PR are expressed to some extent in primary fallopian tube cancer, but both are low. The mutation of p53 gene may be involved in the occurrence of the tumor, and may be used as an index to judge the degree of malignancy and the prognosis of patients one.