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目的 :研究 HL A- DRB基因型在北京地区蒿属花粉过敏变应性鼻炎患者中的分布。方法 :用聚合酶链反应 -序列特异性引物技术 (PCR- SSP) ,检测 HL A- DRB基因型在 41例以蒿属花粉过敏为主的变应性鼻炎患者 (变应性鼻炎组 )及 41例正常健康者 (对照组 )中的分布 ,并分析二者间的分布差异。结果 :变应性鼻炎组 H L A-DRB10 30 1.2及 HL A- DRB40 10 1基因频率分别为 1.2 2 %和 2 9.2 7% ,明显低于对照组 (8.5 4%和 5 1.2 2 % ) ,其差异有显著性意义 (P <0 .0 5 )。结论 :HL A- DRB10 30 1.2及 HL A- DRB40 10 1基因可能是变应性鼻炎发病的抗性基因。
Objective: To study the distribution of HLA-DRB genotypes in patients with allergic rhinitis of artemisia in Beijing. Methods: PCR-SSP was used to detect HLA-DRB genotypes in 41 patients with allergic rhinitis (allergic rhinitis) 41 cases of normal healthy (control group) in the distribution and analysis of the distribution differences between the two. Results: The frequencies of HLA-DRB10 30 1.2 and HLA-DRB40 10 1 alleles in Alzheimer’s disease group were 1.2 2% and 2 9.27%, respectively, which were significantly lower than those in the control group (8.5 4% vs 5.22%) The difference was significant (P <0. 05). CONCLUSION: HL-DRB10 30 1.2 and HL-DRB40 10 1 genes may be responsible for the development of allergic rhinitis.