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目的:探讨质子泵抑制剂在窄带成像内镜下氩离子凝固术治疗Barrett食管(BE)术后应用的疗效。方法:将120例经窄带成像内镜(NBI内镜)检查及病理确诊的BE食管患者随机分成A、B、C 3组,每组40例;3组均于NBI内镜下行氩离子凝固术(APC)治疗,术后均口服瑞巴派特片2周,其中B组术后同时予质子泵抑制剂以奥美拉唑口服治疗(20mg/次,2次/d,8周),C组术后予以奥美拉唑口服治疗(20mg/次,2次/d,8周后改为20mg/次,1次/d,口服36周);3组均于3,6,12个月进行NBI内镜复查,组间进行对比,评价3种方法治疗BE食管的疗效。结果:B、C组于治疗后3,6,12个月的治疗总有效率均高于A组(P<0.05),具有统计学差异;B、C组在治疗后3,6个月复查时治疗总有效率无显著差别(P>0.05),但12个月时C组治疗总有效率高于B组(P<0.05),差异有统计学意义。结论:Barrett食管行NBI内镜下APC治疗术后应行质子泵抑制剂长程维持治疗,可巩固治疗效果、降低BE黏膜复发。
Objective: To investigate the efficacy of proton pump inhibitors in the treatment of Barrett ’s esophagus (BE) after argon plasma coagulation under narrow - band imaging endoscopy. Methods: One hundred and twenty cases of esophageal cancer were examined by narrow-band imaging endoscopy (NBI endoscopy) and pathologically confirmed BE esophageal cancer patients were randomly divided into A, B and C groups, 40 cases in each group. All three groups were treated with argon plasma coagulation (APC). All patients were treated with rebamipide for 2 weeks after operation. The patients in group B were orally treated with omeprazole (20mg / time, 2 times / d, 8 weeks) and C The patients were treated with omeprazole orally (20mg / time, 2 times / d, 8mg / time, once / d, 36 weeks after oral administration); 3 groups NBI endoscopic examination, comparison between groups to evaluate the efficacy of three kinds of methods to treat BE esophagus. Results: The total effective rates at 3, 6 and 12 months after treatment in group B and group C were significantly higher than those in group A (P <0.05), with statistical significance; group B and C were reviewed at 3 and 6 months after treatment (P> 0.05). However, the total effective rate of C group at 12 months was higher than that of B group (P <0.05), and the difference was statistically significant. Conclusion: Barrett’s esophagus under NBI endoscopic APC treatment should be proton pump inhibitor long-term maintenance therapy, can consolidate the treatment effect, reduce BE mucosal recurrence.