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基质细胞衍生因子-1(stromalcell-derived factor 1,SDF-1)是CXC趋化因子家族的成员,CXCR4是目前已知SDF-1的唯一受体。SDF-1/CXCR4在调控胚胎着床,诱导胎盘血管生成,肿瘤细胞趋向性侵袭、转移等方面发挥作用。本文综述SDF-1/CXCR4在女性生殖系统肿瘤中的研究现状,及其在胚胎着床过程中的作用。
Stromal cell-derived factor 1 (SDF-1) is a member of the CXC chemokine family and CXCR4 is the only receptor known to date for SDF-1. SDF-1 / CXCR4 plays a role in regulating embryo implantation, inducing placental angiogenesis, tumor cell invasion and metastasis. This article reviews the current status of SDF-1 / CXCR4 in female reproductive system tumors and its role in embryo implantation.