论文部分内容阅读
目的通过对子痫前期重度患者、正常妊娠妇女凝血功能及肝功能指标检测分析,探讨该疾病血管内皮细胞损伤、凝血系统激活及肝功能受损情况。方法通过使用凝固法,发色底物法,免疫法检测30例正常妊娠足月妇女、25例早发型重度子痫前期、35例晚发型重度子痫前期患者入院未用药前FVIII,FⅨ、AT-III,D-Dimer指标,并采用全自动生化分析仪测定其ALT、AST肝功能指标。结果早发型重度子痫前期组、晚发型重度子痫前期与正常对照组比AT-Ⅲ下降,FⅨ、D-D、ALT、AST升高,且差异具有统计学意义(P<0.01)。结论子痫前期重度尤其是早发型患者存在严重的血管内皮细胞损伤、血液高凝状态,随着病情的发展出现一定程度的肝功能损伤。
Objective To investigate the coagulation function and liver function of severe preeclampsia patients and normal pregnant women to explore the damage of vascular endothelial cells, the activation of coagulation system and the impaired liver function. Methods Thirty normal pregnant women with full-term pregnancy, 25 early-onset severe preeclampsia and 35 late-onset severe preeclampsia were enrolled in this study. The levels of FVIII, FⅨ, AT, -III, D-Dimer index, and the use of automatic biochemical analyzer to measure ALT, AST liver function indicators. Results Compared with AT-Ⅲ and FIX, D-D, ALT and AST in early-onset severe preeclampsia and late-onset severe preeclampsia, the difference was statistically significant (P <0.01). Conclusions Severe preeclampsia, especially early-onset patients, have severe vascular endothelial cell injury and blood hypercoagulability. As the disease progresses, a certain degree of liver damage occurs.