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目的探讨可溶性细胞间粘附分子-1(sICAM-1)在妊娠期高血压疾病(HDCP)患者血浆中的变化及其临床意义。方法研究对象包括33例妊娠期高血压疾病患者(其中子痫前期13例、妊娠期高血压20例),20例正常妊娠妇女(均为孕32-35周)和25例正常未孕妇女,应用酶联免疫吸附试验(ELISA)测定各组研究对象血浆中的sICAM-1水平。结果 sIACM-1未孕组443.68±235.17ng/ml,正常妊娠组664.67±287.33 ng/ml,两者性比差异有统计学意义(P<0.05);与正常妊娠组比较,妊娠期高血压组1145.46±326.67 ng/ml,差异有统计学意义(P<0.05);子痫前期组1402.89±354.67 ng/ml,明显高于正常妊娠组,差异均具有统计学意义(P<0.01);与妊娠高血压组比较差异有显著性(P<0.05)。结论外周血中sICAM-1水平变化与妊娠期高血压疾病(HDCP)密切相关,随着病情加重sICAM-1值明显升高,提示sICAM-1水平上调与妊娠期高血压疾病的发生有关。
Objective To investigate the changes of soluble intercellular adhesion molecule-1 (sICAM-1) in plasma of patients with hypertensive disorder of pregnancy (HDCP) and its clinical significance. Methods The study included 33 patients with gestational hypertension (13 cases of preeclampsia and 20 cases of gestational hypertension), 20 normal pregnant women (all 32-35 weeks old) and 25 normal pregnant women. The level of sICAM-1 in the plasma of each group was measured by enzyme-linked immunosorbent assay (ELISA). Results Compared with the normal pregnancy group, the gestational hypertension group (443.68 ± 235.17ng / ml) and normal pregnancy group (664.67 ± 287.33ng / ml) had statistical significance (P <0.05) 1145.46 ± 326.67 ng / ml, the difference was statistically significant (P <0.05); preeclampsia group 1402.89 ± 354.67 ng / ml, significantly higher than the normal pregnancy group, the difference was statistically significant (P <0.01) There was significant difference between hypertension group (P <0.05). Conclusions The change of sICAM-1 in peripheral blood is closely related to HDCP, with the increase of sICAM-1, the level of sICAM-1 is correlated with the occurrence of hypertensive disorder complicating pregnancy.