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去纤维蛋白原酶(Defibrinogenase)简称去纤酶,是中国科学院昆明动物研究所对特产于我国的尖吻蝮蛇毒进行分离、纯化,得到一种蛇毒酶制剂;经生化、药理诸方面的研究,发现与蛇毒抗凝剂Ancrod有某些类似作用,而又有其独特的作用。实验证明,在动物与正常人体内都有显著的抗凝血和增强纤溶系统活性作用,而且尚有较强的预防实验性动、静脉血栓形成的效应。并对实验肺栓塞具有溶栓作用。去纤酶的临床应用方法简便,效果显著,副作用小等的优点,值得推广应用。药理作用:去纤酶是一种糖蛋白,由17种氨基酸,263个氨基酸残基构
Defibrinogenase, defibrinogenase, is a kind of snake venom enzyme preparation obtained from Kunming Institute of Zoology, Chinese Academy of Sciences. It has been studied in biochemistry and pharmacology, Ancrod has been found to have some similar effects as the anticoagulant Ancrod but has its own unique effect. Experiments show that in animals and normal humans have significant anticoagulant and enhance fibrinolytic activity, but there is a strong preventive effect of experimental arterial and venous thrombosis. And experimental thrombolysis thrombolytic effect. The clinical application of defibrase has the advantages of simple and convenient method, remarkable effect, small side effect and the like, which is worth popularizing and applying. Pharmacological Action: Defibrase is a glycoprotein consisting of 17 amino acids and 263 amino acid residues