论文部分内容阅读
胰岛素是一种有效的治疗糖尿病药物,目前国内最常用的是普通胰岛素注射液,每日必须注射3～4次,为了减轻患者频频注射的痛苦和麻烦,因此将剂型改成栓剂,以代替注射剂,但由于其成本较高,故采用粗制品胰岛素来取代精制品胰岛素制成栓剂,鉴于粗制品中含有异性蛋白因为这种物质存在于药物中,往往在临床使用时易引起病人多种过敏反应,为此目的我们将粗制品胰岛素在动物身上进行了过敏试验。一、实验材料:粗制品胰岛素2.3u/mg精制品胰岛素25.7u/mgpH2.7酸水溶液栓剂基质二、实验方法与结果:取健康无伤豚鼠24只,雌雄各半,体重250g-350g,分成四组,每组六只,第一组为
Insulin is an effective drug for the treatment of diabetes. At present, the most commonly used insulin in our country is insulin injection, which must be injected 3 to 4 times a day. In order to reduce the pain and trouble of frequent injection, the dosage form is replaced by suppository instead of injection , But because of its high cost, so the use of crude insulin instead of refined insulin made of suppository, in view of the crude protein containing foreign material because of the existence of this substance in the drug, often in clinical use easily lead to multiple allergic patients , For which purpose we tested the crude insulin in animals for allergy tests. First, the experimental material: crude insulin 2.3u / mg refined insulin 25.7u / mgpH2.7 acid aqueous suppository matrix II, experimental methods and results: Take healthy guinea pigs 24, male and female, weight 250g-350g, divided into Four groups of six, the first group