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[目的]分析疫苗衍生脊髓灰质炎病毒(VDPV)病例发病原因并探索控制对策。[方法]对发生的VD-PV病例进行个案调查,检测脊灰抗体,测定免疫功能,并定期采集粪便标本分离病毒;对病例所在地及医院进行急性弛缓性麻痹病例主动搜索;对病例所在地及相邻地开展儿童常规接种率快速评价;对密切接触者和周围健康儿童进行粪便标本带毒率调查和脊灰抗体检测。[结果]病例临床诊断为脊髓灰质炎,最终分类诊断为VDPV病例。当地儿童常规免疫接种率较高,并具有较高的脊灰抗体,粪便标本除分离到3株脊灰病毒外,未检出VDPV。为防止VDPV传播,对患儿采取了隔离、消毒措施,在病例所在地及相邻地区开展OPV强化免疫。[结论]该病毒未在当地造成循环。当前应维持高水平的OPV免疫接种率,但随着全球消灭脊灰的进展,应适时修订免疫策略。
[Objective] To analyze the pathogenesis of vaccine-derived poliovirus (VDPV) and explore the control strategy. [Methods] The cases of VD-PV cases were investigated, the anti-polio antibodies were detected, immune function was measured, and stool samples were collected regularly to separate the virus. The cases were located and the hospital was actively searched for acute flaccid paralysis cases. A routine assessment of children’s routine immunization rates was carried out in neighborhoods; a survey on the prevalence of polio samples and poliovirus testing in close contacts and surrounding healthy children. [Results] The case was diagnosed as poliomyelitis and the final classification was diagnosed as VDPV. Local children had higher routine immunization rates and had higher antibodies against polio, and no VDPV was detected except for 3 poliovirus isolated from the stool samples. In order to prevent the spread of VDPV, isolation and disinfection measures were taken for children and OPV intensified immunization was carried out in the area of the cases and adjacent areas. [Conclusion] The virus did not cause circulation in the local area. At present, a high level of OPV vaccination should be maintained, but with the progress of eradicating polio globally, the immunization strategy should be revised in due course.