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目的脑瘫是围产期获得性非进行性脑病导致的先天性运动障碍及姿势异常疾病或综合征。国际上脑瘫的发病率为1%～5%,我国脑瘫的发病率为1.8%～4%,每年新增小儿脑瘫患儿40万。脑瘫目前还无有效的治疗手段。近年来,神经干细胞移植治疗脑瘫的研究越来越多,提供了广阔的空间。人胚胎细胞来源的神经干细胞在形态、功能上具备神经元的特性,与宿主神经元突触联系,接受宿主细胞传递的冲动,与患者大脑发生整合,完成再生功能,从根本上治疗脑瘫。方法提取人胚胎脑组织,体外分化、诱导成神经干细胞,将P2-51-5×105-8神经干细胞通过颈动脉或腰穿的方法移植到病人脑内。一个疗程3～4次,间隔1周,1年2-3个疗程。结果临床治疗25例脑瘫病人,好转23例,无效2例。结论人胚胎神经干细胞移植是治疗脑瘫的最有效手段。
PURPOSE Cerebral palsy is a congenital dyskinesia and postural disorder or syndrome caused by perinatal acquired non-progressive encephalopathy. The incidence of cerebral palsy in the world is 1% ~ 5%, the incidence of cerebral palsy in China is 1.8% ~ 4%, 400,000 children with cerebral palsy are newly added each year. There is no effective treatment for cerebral palsy at present. In recent years, neural stem cell transplantation for the treatment of cerebral palsy more and more research, providing a vast space. Human embryonic stem cell-derived neural stem cells possess neuronal characteristics in morphology and function, synapse contact with host neurons, impulse of host cell delivery, integration with patients’ brains, complete regeneration function, and fundamentally treatment of cerebral palsy. Methods Human embryonic brain tissue was isolated and induced to differentiate into neural stem cells in vitro. P2-51-5 × 105-8 neural stem cells were transplanted into the brain of the patients through carotid artery or lumbar puncture. A course of 3 to 4 times an interval of 1 week 2-3 courses. Results Clinical treatment of 25 cases of cerebral palsy patients, improved in 23 cases, 2 cases. Conclusion Human embryonic neural stem cell transplantation is the most effective treatment for cerebral palsy.