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目的:通过建立动物模型,探讨放射性治疗对SD大鼠唾液中变形链球菌数量的影响。方法:选自20只雌性SD大鼠,随机分成试验组和对照组,每组各10只。经接种变形链球菌后,试验组予以15 Gy/d放射剂量对双侧腮腺进行照射,连续照射30 d。于放射始、30、60 d以及90 d时,观察大鼠唾液中变形链球菌的数量,并于放射90 d时,统计患龋率及根据Keyes评分法评定大鼠患龋状况。结果:随着观察时间的延长,两组大鼠唾液中变形链球菌的数量均不断增加,但实验组各时间点变形链球菌增加数量明显高于对照;放射90 d时,大鼠唾液变形链球菌的数量可达[(8.60±0.21)×10~7]mL,而对照组仅为1(1.91±0.12)×10~7]mL,两组间差异有统计学意义(P<0.05)。实验组的惠龋率及Keyes评分法均明显高于对照组,两组间差异有统计学意义(P<0.05)。结论:放疗可促进SD大鼠唾液中变形链球菌的繁殖而增加其患龋的风险。
Objective: To investigate the effect of radiotherapy on the amount of Streptococcus mutans in saliva of SD rats by establishing an animal model. Methods: Twenty female Sprague-Dawley rats were randomly divided into experimental group and control group, with 10 rats in each group. After inoculation of Streptococcus mutans, the experimental group was given 15 Gy / d dose of radiation on the bilateral parotid gland, continuous irradiation 30 d. At the beginning of radiation, 30, 60 d and 90 d, the number of S. mutans in saliva of rats was observed. At 90 days after radiation, the prevalence of caries was calculated and the caries status of rats was evaluated according to the Keyes score. Results: With the prolongation of observation time, the numbers of S. mutans in the saliva of the two groups increased continuously, but the number of Streptococcus mutans increased significantly at each time point in the experimental group. At 90 days after irradiation, the salivary deformation chain The number of cocci was [(8.60 ± 0.21) × 10 ~ 7] mL, while the control group was only 1 (1.91 ± 0.12) × 10 ~ 7] mL. There was significant difference between the two groups (P <0.05). The caries prevalence and Keyes score in the experimental group were significantly higher than those in the control group, with significant difference between the two groups (P <0.05). Conclusion: Radiotherapy can promote the proliferation of Streptococcus mutans in saliva of SD rats and increase its risk of caries.