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幽门螺杆菌(HP)的发现是消化界的一场革命,它给认识某些上胃肠道疾病的病因、发病机理乃至治疗学均带来重大影响。现已明确HP是慢性胃炎的主要致病因子,且与消化性溃疡、胃粘膜相关性淋巴样组织淋巴瘤(MALT)密切相关。此外,它还参与胃癌的发生。HP的致病性与其能在胃酸环境中定植生存,并产生损伤胃粘膜的毒素,诱发机体一系列炎症、免疫反应有关。 HP在体内呈螺旋状,一端有4～6根鞭毛,该形态使其能在粘
The discovery of Helicobacter pylori (HP) is a revolution in the digestive community that has a significant impact on the etiology, pathogenesis, and even the treatment of certain gastrointestinal diseases. It is now clear that HP is a major causative agent of chronic gastritis and is closely associated with peptic ulcer, gastric mucosa-associated lymphoid tissue lymphoma (MALT). In addition, it is involved in the development of gastric cancer. HP’s pathogenicity and its colonization in the gastric acid environment, survival and produce damage to the gastric mucosa toxins, induced a series of inflammation, immune response. HP is helical in the body with 4 to 6 flagella on one end, making it sticky