论文部分内容阅读
许多细胞因子在下丘脑 垂体 肾上腺轴不同水平上对肾上腺功能具有调控作用 ,在下丘脑白细胞介素(IL) 1β可增加促肾上腺皮质激素释放激素 (CRH)mRNA表达 ,而肿瘤坏死因子α刺激中枢性CRH释放。在垂体水平IL 1β、IL 2及IL 6可增加促肾上腺皮质激素合成。大多细胞因子则在肾上腺水平发挥作用 ,IL 6可引起多种皮质激素显著升高 ,胰岛素样生长因子 1可增加几种类固醇羟化酶活性或诱导重要基因表达 ,碱性成纤维细胞生长因子在肾上腺生长发育及代偿性肥大过程中发挥重要作用 ,转化生长因子 β通过降调类固醇合成酶的基因表达抑制类固醇激素合成 ,表明细胞因子在多个环节均可对肾上腺的功能产生调控作用。
Many cytokines regulate the adrenal function at different levels of the hypothalamus-pituitary-adrenal axis, interleukin (IL) 1β in the hypothalamus increases corticotropin-releasing hormone (CRH) mRNA expression, and tumor necrosis factor-α stimulates central CRH freed. IL 1β, IL 2, and IL 6 at the pituitary level may increase adrenocorticotropic hormone synthesis. Most cytokines play a role at the level of the adrenal gland, IL 6 can cause a significant increase in multiple corticosteroids, insulin-like growth factor 1 increases several steroid hydroxylase activities or induces the expression of important genes, and basic fibroblast growth factor in Adrenal growth and compensatory hypertrophy play an important role in the process, transforming growth factor β by down-regulation of steroidogenic gene expression inhibits steroid hormone synthesis, indicating that cytokines in various aspects of the adrenal function can regulate.