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用 1-甲基 -4苯基 -1,2 ,3 ,6四氢吡啶 (MPTP)可在多种动物上模拟制备成帕金森病模型(PD) ,这些动物PD模型的许多临床特征及主要的生化和病理标志与PD患者十分相似 .分析并总结了MPTP的复杂代谢及其所引起的模型中自由基的产生及其对多巴胺能神经元的损伤机制
The Parkinson’s disease model (PD) has been modeled in a variety of animals using 1-methyl-4-phenyl-1,2,6-tetrahydropyridine (MPTP). Many of the clinical features and predominantly PD models of these animals Of the biochemical and pathological markers and patients with PD are very similar to analyze and summarize the complex metabolism of MPTP and its model caused by the generation of free radicals and dopamine neurons damage mechanism