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目的:研究血管紧张素1型受体(angiotensin type 1 receptor,AT1R)基因A1166C多态性与日本高知地区非酒精性脂肪性肝炎(NASH)易感性的相关性,从基因学角度探讨NASH的发生发展机制,为NASH的预防、诊断和治疗提供一定的理论依据。方法:应用聚合酶链反应-限制性片段长度多态性(PCR-PFLP)方法对日本高知地区96例NASH患者和150例正常人AT1R-A1166C基因多态性进行分析。结果:NASH病例组A等位基因频率与正常对照组相比差异无统计学意义(P>0.05)。NASH病例组AA基因型频率与正常对照组相比差异无统计学意义(P>0.05)。结论:AT1R-A1166C基因多态性与NASH的发生发展尚未显示相关。
Objective: To investigate the association between A1166C polymorphism of angiotensin type 1 receptor (AT1R) gene and the susceptibility to non-alcoholic steatohepatitis (NASH) in Kochi, Japan, and to explore the pathogenesis of NASH from the perspective of genetics Development mechanism for NASH prevention, diagnosis and treatment to provide a theoretical basis. Methods: The polymorphisms of AT1R-A1166C in 96 NASH patients and 150 normal controls were analyzed by PCR-PFLP. Results: There was no significant difference in the frequency of allele A in patients with NASH compared with the control group (P> 0.05). There was no significant difference in AA genotype frequencies between NASH cases and normal controls (P> 0.05). Conclusion: The AT1R-A1166C gene polymorphism has not been correlated with the occurrence and development of NASH.