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目的：观察二氢埃托啡成瘾者的甲状腺功能、胰腺分泌及睾酮变化。方法：用放射免疫法测定１１例男性二氢埃托啡成瘾者与２９例男性海洛因成瘾者及２６例正常对照组血中ＴＳＨ，Ｔ３，Ｔ４，Ｃ肽，胰岛素及睾酮含量。结果：二氢埃托啡成瘾者与正常对照组比较，ＴＳＨ，Ｔ３下降显著（Ｐ＜０．０１）；Ｃ肽和胰岛素增加明显（Ｐ＜０．０１）；Ｔ４下降、睾酮升高，差别不显著（Ｐ＞０．０５）。二氢埃托啡组与海洛因组比较，Ｔ３下降不显著（Ｐ＞０．０５）；ＴＳＨ和Ｔ４下降显著（Ｐ＜０．０１）；Ｃ肽、胰岛素、睾酮升高显著（Ｐ＜０．０１）。结论：二氢埃托啡成瘾者垂体甲状腺功能受抑制，胰腺和睾酮分泌升高
Objective: To observe the changes of thyroid function, pancreatic secretion and testosterone in patients with dihydroetorphine addiction. Methods: The contents of TSH, T3, T4, C-peptide, insulin and testosterone in 11 male DHEA and 29 male heroin addicts and 26 normal controls were measured by radioimmunoassay. Results: Compared with the normal control group, the TSH and T3 decreased significantly (P <0.01), the C peptide and insulin increased significantly (P <0.01), the levels of T4 decreased, the levels of testosterone increased, The difference was not significant (P> 0.05). Compared with the heroin group, there was no significant decrease in T3 (P> 0.05); the levels of TSH and T4 decreased significantly (P <0.01); the C peptide, insulin and testosterone increased significantly (P <0. 01). CONCLUSION: Thyroid function is inhibited by dihydroetorphine addicts and the secretion of pancreatic and testosterone is increased