论文部分内容阅读
用乙醛酸诱发荧光及放射免疫分析法进一步研究，氯仿诱发小鼠心室颤动（ＶＦ）是由于内源性儿茶酚胺（ＣＡ）快速释放和利血平可防止ＶＦ的发生．实验结果表明：快速吸入氯仿引起小鼠心室及肾上腺ＣＡ释放而致颤，因此，单独耗竭心室ＣＡ或摘除肾上腺均不能防止ＶＦ的发生．利血平防颤与它耗竭ＣＡ，提高心室ｃＧＭＰ水平和降低ｃＡＭＰ／ｃＧＭＰ比值有关．提示：ＣＡ参与ＶＦ发生可能与环核苷酸水平有关；利血平耗竭ＣＡ，也影响ｃＧＭＰ水平．
Further studies using glyoxylate-induced fluorescence and radioimmunoassay revealed that chloroform-induced ventricular fibrillation (VF) was due to the rapid release of endogenous catecholamine (CA) and reserpine prevention of VF. The experimental results show that the rapid inhalation of chloroform caused the release of CA in the ventricular and adrenal of mice, resulting in tremor. Therefore, the exhaustion of ventricular CA alone or the removal of the adrenal gland can not prevent the occurrence of VF. Anti-fibrillation and its depletion of CA, improve ventricular cGMP levels and reduce cAMP / cGMP ratio. Tip: CA involved in the occurrence of VF may be related to cyclic nucleotide levels; reserpine depletion of CA, also affect cGMP levels.