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十几年来由于过多使用ACTH或皮质类固醇制剂,随之在仃药后出现了许多症状,甚至造成仃药困难,最严重者为下丘脑—垂体—肾上腺皮质(H-PA)功能受抑制。作者观察一组长期服用皮质类固醇,每日剂量相当强的松10—60mg,病程从一年半—20年不等的病人。采用竞争性蛋白结合放射测定法以检查血浆考的松浓度,以Glenn和Nelson氏法测定24小时尿17酮(17-KS)和尿17羟(17-OHCS),以及用α~(1-24)ACTH 250μg作快速AC-TH试验(60分钟法)等以估计HPA系统功能,结
More than 10 years due to excessive use of ACTH or corticosteroid preparations, followed by Ding in medicine after the emergence of a number of symptoms, and even Ding Ding medicine difficult, the most serious of the hypothalamus - pituitary - adrenal (H-PA) function was inhibited. The authors looked at a group of long-term corticosteroids, daily doses of 10-60mg of prednisone, duration from a year and a half to 20 years of patients. Urine 17-KS and 17-OHCS were measured 24 hours by Glenn and Nelson’s method using competitive protein-binding radiometric assay for plasma testosterone, 24) ACTH 250 μg for rapid AC-TH test (60 min method), etc. to evaluate HPA system function, junction