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研究国产克林霉素对临床分离的７７株需氧菌和９９株厌氧菌的体外抗菌活性，并与林可霉素及其他抗菌药物进行了比较。结果表明：克林霉素对肺炎球菌的ＭＩＣ９０为０．０６ｍｇ／Ｌ，对溶血性链球菌的ＭＩＣ５０为０．０３ｍｇ／Ｌ，均强于林可霉素；对金葡球菌的ＭＩＣ５０为０．０３ｍｇ／Ｌ，强于林可霉素和青霉素Ｇ；对嗜血流感杆菌具中度活性，其ＭＩＣ５０为４ｍｇ／Ｌ；对Ｄ群链球菌作用较差，ＭＩＣ５０＞３２ｍｇ／Ｌ；对脆弱类杆菌的作用比林可霉素强４倍，ＭＩＣ９０分别为４和１６ｍｇ／Ｌ，但较甲硝唑作用稍差；对革兰氏阳性厌氧球菌，克林霉素与青霉素Ｇ的ＭＩＣ９０均≤０．０６ｍｇ／Ｌ，强于其他测试药物；对丙酸杆菌和真杆菌的ＭＩＣ９０分别为≤０．０６和０．１２５ｍｇ／Ｌ。
In vitro antibacterial activity of domestic clindamycin against 77 aerobic and 99 anaerobic bacteria isolated from clinical isolates was investigated and compared with lincomycin and other antibacterials. The results showed that the MIC90 of clindamycin to pneumococcus was 0.06 mg / L and the MIC50 to hemolytic streptococcus was 0.03 mg / L, both of which were stronger than that of lincomycin. MIC50 of Staphylococcus aureus was 0. 03mg / L, stronger than lincomycin and penicillin G; moderate activity against Haemophilus influenzae, the MIC50 of 4mg / L; group D streptococci poor, MIC50> 32mg / L; The effect of bacilli was 4 times stronger than that of lincomycin, MIC90 was 4 and 16 mg / L, respectively, but its effect was slightly worse than that of metronidazole. The MIC90 of Gram-positive anaerobic bacteria, clindamycin and penicillin G were all ≤ 0.06mg / L, stronger than other test drugs; MIC90 of Propionibacterium and Eubacterium were respectively 0.06 and 0.125mg / L.