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目的研究食管胃交界小细胞神经内分泌癌(NEC)的临床病理特点及免疫组化特征。方法分析10例食管胃交界小细胞NEC患者的临床病理资料和免疫组化结果。结果 10例患者中,9例均在3年内死于复发及转移;组织分型为5例混合型,5例小细胞型;9例神经细胞粘附分子(CD56)(+)、6例低分化神经内分泌肿瘤(NSE)(+)、5例嗜铬素(Cg A)(+)、5例突触素(Syn)(+)。结论食管胃交界小细胞NEC好发于中老年人,恶性度高,侵袭性强,CD56、Cg A和Syn联合检测可提高食管胃交界小细胞NEC的诊断率,手术及化疗可能是重要和有效的治疗方法。
Objective To study the clinicopathological features and immunohistochemical characteristics of small cell neuroendocrine carcinoma (NEC) at the junction of esophageal and gastric. Methods The clinicopathological data and immunohistochemical results of 10 patients with esophageal and gastric small cell NEC were analyzed. Results Nine of 10 patients died of recurrence and metastasis within 3 years. Tissue typing was performed in 5 cases of mixed type and 5 cases of small cell type. 9 cases of CD56 (+), 6 cases of low Differentiated neuroendocrine tumors (NSE) (+), 5 cases of chromogranin (CgA) (+), 5 cases of synaptophysin (+). Conclusion The small cell NEC in the esophagogastric junction mainly occurs in the middle-aged and elderly patients. The combined detection of CD56, Cg A and Syn can improve the diagnostic rate of small cell NEC in the esophagogastric junction. Surgical and chemotherapy may be important and effective The treatment.