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采用混酸氧化制备羧酸化单壁碳纳米管(c-SWNTs),探讨c-SWNTs对盐酸表柔比星(EPI)吸附能力与释放行为。结果表明:羧酸化修饰明显改善了单壁碳纳米管(SWNTs)的水分散性;EPI在c-SWNTs上的吸附符合准二级吸附动力学,在240 min后基本达到吸附平衡;c-SWNTs表面存在多分子层的活性作用位点,Freundlich模式比较适合用于表达EPI在c-SWNTs表面的吸附过程;碱性条件和低温条件有利于EPI在c-SWNTs表面的吸附;与多壁碳纳米管、羧酸化多壁碳纳米管及SWNTs相比,c-SWNTs对EPI的吸附能力最大。EPI在c-SWNTs的释放行为具有pH依赖性,在酸性环境中有较大的释放行为,这为其在癌细胞的靶向释放、控释研究提供了理论基础。
Carboxylated single-walled carbon nanotubes (c-SWNTs) were prepared by mixed acid oxidation to investigate the adsorption capacity and release behavior of c-SWNTs on epirubicin hydrochloride (EPI). The results showed that carboxylate modification significantly improved the water dispersibility of single-walled carbon nanotubes (SWNTs). The adsorption of EPI on c-SWNTs was in accordance with quasi-second order adsorption kinetics and reached the equilibrium state after 240 min. Freundlich model is more suitable for the adsorption of EPI on the surface of c-SWNTs; alkaline conditions and low temperature conditions are conducive to the adsorption of EPI on the surface of c-SWNTs; and multi-walled carbon nano Compared with SWNTs, c-SWNTs exhibited the highest adsorption capacity of EPI on CNTs, carboxylated MWCNTs and SWNTs. The release behavior of EPI in c-SWNTs is pH-dependent and has a greater release behavior in acidic environment, which provides a theoretical basis for its targeted release and controlled release studies in cancer cells.