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聚肌胞加左旋咪唑治疗溃疡性结肠炎(UC)目前国内外尚未见报道,我们自1990年以来对住院及门诊治疗的UC患者进行了上述药物的联合治疗观察,报道如下.1 材料和方法1.1 病例选择 按1978年杭州消化系病所定溃疡性结肠炎的诊断标准,选择门诊及住院病人14例,其中男8例,女6例.年龄27～43岁,平均年龄38.7±4.7岁,临床上依其严重程度,按Truelove和witts所定标准(即活动指数AI=60×血便+0.5×血沉+13×大便次数-4×血红蛋白-15×白蛋白+200,<150为轻度,150～220为中度,>200为重度)分为轻、中、重三度,用药前1周用乙状结肠镜检,于直肠10cm及炎症重处活检,按Baron’s分级.分为Ⅰ、Ⅱ、Ⅲ度、疗程结束后再行镜检.1.2治疗方法 第一周聚肌胞2mg肌注,每周2次,若无低热,第二周改为4mg肌注,隔日1次;左旋咪唑为50mg,每日3次,每周连服3天.停4天,两药共用8周,用药期间注意监测肝功能及血象.
Poly-levamisole and levamisole for the treatment of ulcerative colitis (UC) at home and abroad have not been reported at present, we have treated inpatients and outpatients since 1990, the combined treatment of these drugs were observed in the following reports.1 Materials and Methods 1.1 Case Selection According to the diagnostic criteria for ulcerative colitis in Hangzhou in 1978, 14 outpatients and inpatients were selected, including 8 males and 6 females, aged from 27 to 43 years with a mean age of 38.7 ± 4.7 years and clinically According to its severity, according to the criteria set by Truelove and Witts (ie activity index AI = 60 × blood stool + 0.5 × ESR + 13 × number of stool - 4 × hemoglobin-15 × albumin +200, <150 is mild, 220 for the moderate,> 200 for the severe) is divided into mild, moderate and severe degree, 1 week before treatment with sigmoidoscopy in the rectum 10cm and inflammatory biopsy, according to Baron’s classification is divided into Ⅰ, Ⅱ, Ⅲ degree , After the end of treatment again microscopic examination.1.2 treatment polyglutamic acid 2mg intramuscular injection, twice a week, if no fever, the second week to 4mg intramuscular injection, every other day; levamisole 50mg, each 3 times a day, even for 3 days a week. Stop 4 days, two drugs shared for 8 weeks, medication attention to monitor liver function and blood.