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在丙型肝炎病毒(HCV)感染者中约有一半病人发展为慢性肝病(CLD),而另一半病人没有肝脏损害的组织学变化。宿主的免疫反应可能在导致如此不同的结果中起着重要作用。已知组织相容性基因位点抗原(HLA)与对HBV的免疫反应有关,但其与HCV的关系尚未见报道。在本研究中,作者评价了HLA-Ⅱ类等位基因(DR和DQ),特别是HLA-DR5对HCV感染转归的影响。 作者将87例抗-HCV阳性(ELISA-2)的病人根据有无肝病存在分为两组。第一组包括36例抗-HCV阳性的无症状供血者(男
About half of patients with hepatitis C virus (HCV) develop chronic liver disease (CLD), while the other half have no histological changes of liver damage. The host’s immune response may play an important role in causing such a different outcome. It is known that histocompatibility gene-site antigen (HLA) is related to the immune response to HBV, but its relationship with HCV has not been reported yet. In this study, we evaluated the effect of HLA class II alleles (DR and DQ), in particular HLA-DR5, on the outcome of HCV infection. The authors divided 87 patients with anti-HCV (ELISA-2) into two groups based on the presence or absence of liver disease. The first group consisted of 36 anti-HCV positive asymptomatic donors (male