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目的了解混苯和噪声联合暴露对工人脂肪肝患病率的影响。方法根据工作场所混苯与噪声暴露情况将634名工人分成4组,收集研究对象的基本情况,进行外周血谷丙转氨酶(ALT)、甘油三酯(TG)检测及肝脏B超检查。结果混苯与噪声联合暴露组工人脂肪肝患病率为33.3%,ALT偏高率为23.8%,明显高于对照组的18.0%和14.0%(均P<0.05);logistic回归分析表明,联合暴露组工人脂肪肝患病风险升高,OR=2.629(95%CI=1.412~4.898),外周血TG浓度和体质指数(BMI)升高者脂肪肝患病风险也增加,OR值分别为1.602(95%CI=1.320~1.946)和1.292(95%CI=1.187~1.406)。结论外周血TG、BMI及混苯与噪声联合暴露可增加接触工人患脂肪肝的风险。
Objective To understand the effect of combined benzene and noise exposure on the prevalence of fatty liver in workers. Methods 634 workers were divided into 4 groups according to the mixed benzene and noise exposure in the workplace. The basic conditions of the study subjects were collected and the levels of ALT, TG and liver B ultrasound were measured. Results The prevalence of fatty liver was 33.3% in workers exposed to mixed benzene and noise, and the high rate of ALT was 23.8%, which was significantly higher than that of the control group (18.0% vs 14.0%, P <0.05). Logistic regression analysis showed that the combination The risk of fatty liver in the exposed group was higher (OR = 2.629, 95% CI = 1.412-4.898), and the risk of fatty liver increased with the increase of peripheral blood TG and body mass index (BMI), the OR values were 1.602 (95% CI = 1.320-1.946) and 1.292 (95% CI = 1.187-1.406). Conclusion Peripheral blood TG, BMI and mixed benzene and noise exposure may increase the risk of exposure to fatty liver in workers.