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目的:探讨血尿酸(SUA)水平与冠状动脉病变程度的关系。方法:将268例疑似冠心病(CHD)患者,经冠状动脉造影分为冠心病组198例和非冠心病组70例;冠心病组又分为单支病变组80例,双支病变组56例,三支病变组62例。分别检测各组研究对象血尿酸含量,同时记录年龄、性别、吸烟、高血压、糖尿病、血尿酸及冠状动脉造影结果,分析血尿酸与已知冠心病主要危险因素、冠状动脉病变程度的相关性。结果:冠心病组血尿酸水平(395.35±84.40)μmol/L,显著高于非冠心病组(282.20±66.68)μmol/L(P<0.05)。单支病变组(338.48±77.36)μmol/L、双支病变组(399.62±84.36)μmol/L、三支病变组(445.16±92.20)μmol/L,血尿酸水平呈递增趋势,各组之间的差异有统计学意义。结论:血尿酸水平可反映冠状动脉病变严重程度。降尿酸治疗有望成为心血管疾病防治的一种新途径。
Objective: To investigate the relationship between the level of serum uric acid (SUA) and the severity of coronary artery disease. Methods: A total of 268 patients with suspected coronary heart disease (CHD) were divided into coronary heart disease group (198 cases) and non-coronary heart disease group (70 cases) by coronary angiography. Coronary heart disease group was further divided into single vessel disease group (80 cases), double vessel disease group Cases, three lesions in 62 cases. The levels of serum uric acid in each group were detected. Age, gender, smoking, hypertension, diabetes mellitus, serum uric acid and coronary angiography were recorded. The correlation between serum uric acid and major risk factors of coronary heart disease and coronary artery disease were analyzed. . Results: The level of serum uric acid in coronary heart disease group (395.35 ± 84.40) μmol / L was significantly higher than that in non-coronary heart disease group (282.20 ± 66.68) μmol / L (P <0.05). (338.48 ± 77.36) μmol / L in single vessel disease group, 399.62 ± 84.36 μmol / L in double vessel disease group, and 445.16 ± 92.20 μmol / L in three vessel disease group. The serum uric acid level showed an increasing trend among the three groups The difference was statistically significant. Conclusion: Serum uric acid level can reflect the severity of coronary artery disease. Uric acid lowering treatment is expected to become a new way of prevention and treatment of cardiovascular diseases.