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为探讨钙拮抗剂异博定是否能增强平阳霉素对人癌细胞的毒性,利用体外培养人喉癌细胞对二药单用和合用效果进行了比较研究.结果表明,非抑制浓度的异博定使平阳霉素的半抑制浓度显著下降;平阳霉素与异博定联合处理后,细胞存活率下降到单用平阳霉素的1/16～1/43;异博定能增强平阳霉素对人喉癌细胞的毒性,原因之一是异博定促进了细胞对平阳霉素的吸收,使药物在细胞内的积聚增加,但对该药外排无显著影响.
In order to explore whether the calcium antagonist isoborracene can enhance the toxicity of pingyangmycin to human cancer cells, the effects of single and combined use of the two drugs in human laryngeal carcinoma cells were compared in vitro.Results showed that non-inhibitory concentration of The lethal concentration of Pingyangmycin significantly decreased; Pingyangmycin and isoboridine combined treatment, the cell survival rate dropped to 1/16 ~ 1/43 Pingyangmycin alone; isoprothiazide can increase Pingyangmycin One of the reasons for the toxicity of human laryngeal cancer cells is that ibuprofen promotes the absorption of pingyangmycin in cells and increases the accumulation of the drug in the cells but has no significant effect on the efflux of the drug.