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目的:观察三维适形放疗联合艾素卡铂化疗治疗局部晚期非小细胞肺癌的临床疗效与不良反应。方法:106例经病理证实的非小细胞肺癌患者(Ⅲa期29例,Ⅲb期77例)行三维适形放疗,放疗的第1天联合艾素卡铂同步化疗。结果:全组完全缓解(CR)率4.7%,部分缓解(PR)率72.6%,总有效率为77.4%。1、2、3年局部控制率和生存率分别为87.5%、50.0%、35.7%和87.5%、46.7%、28.6%。结论:三维适形放疗联合艾素卡铂化疗治疗局部晚期非小细胞肺癌局部控制率和生存率较高。
Objective: To observe the clinical efficacy and adverse reactions of three-dimensional conformal radiotherapy combined with doxorubicin chemotherapy in the treatment of locally advanced non-small cell lung cancer. Methods: One hundred and six patients with pathologically confirmed non-small cell lung cancer (29 cases in stage Ⅲa and 77 cases in stage Ⅲb) underwent three-dimensional conformal radiotherapy. On the first day of radiotherapy, they were treated with cisplatin and cisplatin. Results: The complete remission (CR) rate of 4.7%, partial response (PR) rate of 72.6%, the total effective rate was 77.4%. The local control rates and survival rates at 1, 2 and 3 years were 87.5%, 50.0%, 35.7% and 87.5%, 46.7% and 28.6% respectively. Conclusion: Three-dimensional conformal radiotherapy combined with doxorubicin chemotherapy for locally advanced non-small cell lung cancer has a high local control rate and survival rate.