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中毒性耳聋为第八对颅神经遭受毒素损害所致。毒素可分为外来与内生两种。外来毒素对内耳有损害作用者称为耳毒类,如抗菌素、奎宁、水杨酸盐、磺胺类药、利尿酸、利尿灵(呋喃苯胺酸)、土荆芥油、氮芥,烟碱、酒精、重金属(汞、铅、砷)、一氧化碳等。其中以多种抗菌素和奎宁致聋者最多见。内生毒素系由体内传染病灶的细菌产生,损害内耳,导致耳聋,但此种关系各家论说不一,未能肯定。我院耳科门诊自1979年4月17日至7月15日,三个月中有详细记录及听力检查的耳聋患儿内,共有感觉神经性耳聋139人。后天性感觉神经性耳聋114人,其中用耳毒性抗菌素者78人,6人因有其他传染病史,不能
Toxic deafness is the eighth cranial nerve suffering from toxin damage. Toxins can be divided into two types of exogenous and endogenous. Extraneous toxins have a detrimental effect on the inner ear known as ototoxicity, such as antibiotics, quinine, salicylates, sulfonamides, uric acid, diuretic (furosemide acid), catminta oil, nitrogen mustard, nicotine , Alcohol, heavy metals (mercury, lead, arsenic), carbon monoxide and so on. Among them, a variety of antibiotics and quinine deaf were the most common. Endotoxins are produced by bacteria that infect the body in the body, damaging the inner ear, causing deafness, but the various arguments of this relationship vary and are not confirmed. Our hospital ear clinic since April 17, 1979 to July 15, three months with detailed records and hearing tests in children with deafness, a total of sensory deafness in 139 people. Acquired sensory neuropathy deafness 114 people, including 78 people with ototoxic antibiotics, 6 people because of other infectious diseases history, can not