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目的:探讨不同分娩方式与早发型母乳性黄疸发病率的关系及和胃动素(MOT)、胃泌素(GAS)水平的相关性。方法:由专人对该院产科出生正常的新生儿218例进行监测,其中剖宫产136例,自然分娩82例,将符合早发型母乳性黄疸诊断标准的50例对象进一步采集血液标本,通过放射免疫法测定MOT和GAS水平。结果:剖宫产组早发型母乳性黄疸的发病率为27.49%,高于正常分娩组发病率14.63%(P<0.05);剖宫产组MOT、GAS的水平分别为(206.84±32.10)ng/L和(94.54±16.42)ng/L明显低于正常分娩组(256.20±28.32)ng/L和(137.06±16.15)ng/L(P<0.001)。结论:剖宫产分娩的新生儿较自然分娩的新生儿更易发生早发型母乳性黄疸,且同时有胃肠激素MOT、GAS水平的降低。对剖宫产分娩的新生儿更应严密监测黄疸的发生,及早干预。
Objective: To investigate the relationship between different modes of delivery and the incidence of early-onset breast milk jaundice and its correlation with motilin (MOT) and gastrin (GAS) levels. Methods: A total of 218 newborns with normal cesarean section were enrolled in this hospital. Among them, 136 cases were cesarean and 82 were born spontaneously. Blood samples were collected from 50 subjects who met the diagnostic criteria for early-onset breast milk jaundice. Immunoassay to determine MOT and GAS levels. Results: The incidence of early-onset breast milk jaundice in the cesarean section group was 27.49%, higher than that in the normal delivery group (14.63%, P <0.05). The levels of MOT and GAS in the cesarean section group were 206.84 ± 32.10 ng / L and (94.54 ± 16.42) ng / L were significantly lower than those in normal delivery group (256.20 ± 28.32) ng / L and (137.06 ± 16.15) ng / L, respectively. Conclusions: Newborn infants born by cesarean delivery are more likely to develop early-onset breast milk jaundice than newborn infants born spontaneously and with decreased levels of gastrointestinal hormones MOT and GAS. Neonatal delivery of cesarean section should be closely monitored jaundice, early intervention.