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目的总结与分析无锡地区2009上半年药品不良反应(ADR),为临床合理用药提供参考。方法回顾性分析2009年上半年江苏省不良反应监测中心收到的无锡地区2158例《药品不良反应/事件报告表》,对其中79例严重的不良反应报告进行重点分析。结果在发生的ADR中,女性发生比例较高(男∶女为1∶1.17),小儿发生ADR比例也较大(15.01%),静脉给药(74.28%)和联合用药(26.00%)易发生ADR,抗微生物药(60.76%)、抗肿瘤药(13.92%)是引发严重不良反应的主要药物,严重不良反应的临床表现主要为过敏样反应。结论临床用药时应综合分析药物与患者的关系,合理选择药物并加强监测,以减少ADR的发生。
Objective To summarize and analyze the adverse drug reaction (ADR) in Wuxi in the first half of 2009 and provide a reference for clinical rational drug use. Methods A retrospective analysis of 2158 cases of adverse drug reaction / incident reports received by Jiangsu Adverse Reaction Monitoring Center in Wuxi in the first half of 2009 was conducted, and 79 serious adverse reactions reports were analyzed. Results ADR occurred in a relatively high proportion of women (male: female: 1: 1.17), ADR in children was also greater (15.01%), intravenous (74.28%) and combination (26.00%) were more likely to occur ADR, antimicrobial drugs (60.76%), anti-tumor drugs (13.92%) are the main drugs that cause serious adverse reactions. The main clinical manifestations of serious adverse reactions are allergic reactions. Conclusion Clinical drug should be comprehensive analysis of the relationship between drugs and patients, rational choice of drugs and strengthen monitoring to reduce the occurrence of ADR.