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绝大多数的急性早幼粒细胞白血病(APL)患者由于使用维甲酸和砷剂获得治愈〔1〕。文献认为APL患者诱导治疗期间不建议使用粒细胞集落刺激因子(G-CSF),除非合并严重感染〔2〕。我们发现1例APL患者诱导治疗期间使用G-CSF合并严重并发症,现报告如下。1病例资料患者,女,37岁,因“皮肤瘀斑、乏力1个月余”于2014年8月18日入院。入院后完善检查,血常规:白细胞3.5×109/L,中性粒细胞49%,淋巴细
The vast majority of patients with acute promyelocytic leukemia (APL) are treated with retinoids and arsenic (1). Literature that APL patients induction therapy is not recommended during the use of granulocyte colony stimulating factor (G-CSF), unless combined with severe infection 〔2〕. We found that 1 patient with APL induced G-CSF during treatment with serious complications, are reported as follows. 1 case data patients, female, 37 years old, because of “skin ecchymosis, fatigue more than 1 month ” was admitted on August 18, 2014. Perfection after admission examination, blood: white blood cells 3.5 × 109 / L, 49% of neutrophils, lymphocytes