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目的对已感染幽门螺杆菌(Hp)的成人特发性血小板减少性紫癜(ITP)患者行抗Hp治疗的临床研究,探讨ITP与Hp之间的关系以及抗Hp在ITP治疗中的作用。方法以14C尿素呼气试验筛选Hp感染的ITP患者,应用奥美拉唑、克拉霉素及羟氨苄青霉素三联治疗Hp,观察血小板计数变化情况。结果本组26例患者经抗Hp治疗后血小板数有明显上升,与治疗前比较差异有统计学意义(P<0.05)。21例Hp转阴。Hp转阴患者的血小板回升程度较未转阴者更明显,差异有统计学意义(P<0.01)。结论抗Hp治疗可提高受Hp感染的ITP患者血小板数量。
Objective To study the anti-Hp therapy in adults with idiopathic thrombocytopenic purpura (ITP) who have been infected with Helicobacter pylori (Hp) and to explore the relationship between ITP and Hp and the role of anti-Hp in ITP therapy. Methods Hp-infected ITP patients were screened by 14C urea breath test. Opioprazole, clarithromycin and amoxicillin triple therapy were used to treat Hp, and the change of platelet count was observed. Results The number of platelets in 26 patients after anti-Hp treatment increased significantly compared with that before treatment (P <0.05). 21 cases of Hp negative. Hp negative patients with platelet recovery than those who did not turn more obvious, the difference was statistically significant (P <0.01). Conclusion Anti-Hp therapy can increase the number of platelets in patients with Hp-infected ITP.