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目的探讨多普勒超声血流显像联合血清CA125、CA199在早期卵巢恶性肿瘤诊断中的价值。方法对2002年1月至2004年11月广州医学院第二附属医院等2家医院的99例卵巢肿瘤患者及42例对照组妇女分别进行多普勒超声及血清CA125、CA199检测,并分别以血清CA125>35kU/L、CA125>100kU/L;CA199>37kU/L、CA199>70kU/L;阻力指数(RI)<0.5、RI<0.6作为阳性结果,比较各种指标对卵巢恶性肿瘤预测的敏感性、特异性、阳性预测值和阴性预测值。结果卵巢恶性肿瘤患者血清CA125、CA199水平明显高于对照组和卵巢良性肿瘤组,而良性肿瘤组和对照组间差异无显著性意义(P>0.05)。多普勒血流显像,恶性肿瘤组RI显著低于良性肿瘤组。单独应用CA125>100kU/L敏感性为78.4%,特异性为88.4%,单独应用CA199>70kU/L敏感性为49.0%,特异性为86.0%。多普勒超声(RI<0.5)联合上述两种血清学指标,敏感性为94.2%,特异性为95.3%。结论血清CA125、CA199联合多普勒超声血流显像可明显提高卵巢恶性肿瘤诊断的敏感性和特异性。
Objective To investigate the value of Doppler ultrasound imaging combined with serum CA125 and CA199 in the diagnosis of early ovarian cancer. Methods From January 2002 to November 2004, 99 cases of ovarian cancer patients and 42 control women in two hospitals, such as the Second Affiliated Hospital of Guangzhou Medical College, were examined with Doppler ultrasound and serum CA125 and CA199 respectively Serum CA125> 35kU / L, CA125> 100kU / L; CA199> 37kU / L, CA199> 70kU / L; resistance index (RI) <0.5, RI <0.6 as a positive result, compared various indicators of ovarian cancer prediction Sensitivity, specificity, positive predictive value and negative predictive value. Results The serum levels of CA125 and CA199 in patients with ovarian cancer were significantly higher than those in control group and benign ovarian tumor group, but there was no significant difference between benign tumor group and control group (P> 0.05). Doppler flow imaging, RI in malignant group was significantly lower than that in benign tumor group. The sensitivity and specificity of CA125> 100kU / L alone were 78.4% and 88.4%, respectively. The sensitivity and specificity of CA199> 70kU / L alone were 49.0% and 86.0%, respectively. Doppler ultrasound (RI <0.5) combined with the above two serological indicators, the sensitivity was 94.2% and the specificity was 95.3%. Conclusion Serum CA125, CA199 combined with Doppler ultrasound imaging can significantly improve the diagnosis of ovarian cancer sensitivity and specificity.