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前 言 组蛋白是染色质中与DNA结合的碱性蛋白质,一般有五种,即组蛋白H_1、H_2A、H_2B、H_3和H_4。其中组蛋白H_1具有种属和组织特异性。核小体是染色质的基本结构单位,由组蛋白与DNA结合而成。目前认为组蛋白H_1可能参与基因表达的调控作用,主要是通过改变染色质的结构。肿瘤的病因可以是多种的,不论是化学、病毒或物理等因素致癌,最终导致细胞癌变的机理,基本上可归纳为两种观点:体细胞突变和基因表达的调控失常。但二者都认为癌变时是存在着基因表达调控失常的。 二甲氨基偶氮苯(DAB)可诱发大鼠肝癌,对其致癌机理进行了许多研究。仍没有明
Histone is a basic protein that binds to DNA in chromatin. There are five types of histones: histone H_1, H_2A, H_2B, H_3 and H_4. Histone H 1 has species and tissue specificity. Nucleosomes are the basic structural units of chromatin, formed by the combination of histones and DNA. At present, it is thought that histone H_1 may be involved in the regulation of gene expression, mainly by changing the chromatin structure. The causes of cancer can be a variety of, whether it is chemical, viral or physical factors such as carcinogenesis, the ultimate cause of cancer cells, the mechanism can basically be summarized in two ways: somatic mutations and gene expression disorders. However, both suggest that there is an abnormal regulation of gene expression during carcinogenesis. Dimethyl aminoazobenzene (DAB) can induce liver cancer in rats, and many studies on its carcinogenic mechanism. Still not clear