维生素与恩他卡朋治疗左旋多巴诱发的高同型半胱氨酸血症:一项随机对照研究

• 作 者: Postuma R.B. Espay A.J. Zadikoff C. 牛亚利
• 机 构: Dr.Department of Neurology L7-305 Montreal General Hospital,1650 Cedar Avenue,Montreal,Que.H3G 1A4,C
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2006年12期
• 关键词: 恩他卡朋 左旋多巴 同型半胱氨酸 维生素 帕金森病 维生素治疗 叶酸 安慰剂 血清 安慰剂对照

Elevated homocysteine is associated with increased risk of heart disease,stroke,and dementia.Therapy of Parkinson disease(PD)with levodopa elevates homocysteine.The authors conducted a 6-week,multicenter,randomized,double-blind,placebo-controlled trial to test whether folate 1 mg/vitamin B12 500 μg or entacapone reduced serum homocysteine in 35 levodopa-treated PD patients.Levodopa initiation caused a small elevation in homocysteine.Vitamin therapy,but not entacapone,resulted in a decrease in homocysteine compared to placebo.

Elevated homocysteine ​​is associated with increased risk of heart disease, stroke, and dementia. Therapy of Parkinson disease (PD) with levodopa elevates homocysteine. The authors conducted a 6-week, multicenter, randomized, double-blind, placebo-controlled trial to test Whether folate 1 mg / vitamin B12 500 μg or entacapone reduced serum homocysteine ​​in 35 levodopa-treated PD patients. Levodopa initiation caused a small elevation in homocysteine. Vitamin therapy, but not entacapone, resulted in a decrease in homocysteine ​​compared to placebo.