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为了探讨胃镜下可疑恶性溃疡组织MG7-Ag表达对其临床随访、二次活检的辅助指导价值,对58例经首次胃镜检查可疑恶性溃疡、活检、病理未能确诊者的病理标本进行MG7-Ag的ABC免疫组化染色,同时进行1～72周(平均7周)临床随访。所有病人均再次胃镜复查,组织活检,病理检查。结果表明,MG7-Ag阳性表达30例中有19例二次活检病理检查确诊为胃癌(63.3%),阴性组28例中有5例确诊为胃癌(17.9%),两组胃癌检出率差异有非常显著意义(P<0.01)。结论:MG7-Ag阳性表达的胃镜下可疑恶性溃疡与胃癌关系密切,对这部分病人进行密切随访,有助于胃癌的早期发现。
In order to investigate the value of MG7-Ag expression in suspicious malignant gastric mucosa under endoscopy for its clinical follow-up and secondary biopsy, the pathological specimens of 58 patients with suspicious malignant ulcer, biopsy and pathology confirmed by first gastroscopic examination were subjected to MG7-Ag Of ABC immunohistochemical staining, while 1 to 72 weeks (average 7 weeks) clinical follow-up. All patients were again gastroscopy review, biopsy, pathological examination. The results showed that of the 30 cases with positive expression of MG7-Ag, 19 cases were diagnosed as gastric cancer by secondary biopsy (63.3%) and 5 cases (17.9%) were negative by gastric biopsy. The difference between the two groups was statistically significant There is a very significant (P <0.01). CONCLUSION: The suspicious malignant ulcer with MG7-Ag expression under endoscopy is closely related to gastric cancer. Close follow-up of this group of patients is helpful for the early detection of gastric cancer.