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微小病变型肾病(简称MCN,下同)常常又被称为类脂性肾病,是肾病综合征中最常见的一种类型。在儿童肾病综合征中约占85％成人占20～30％。在治疗上对皮质激素及免疫抑制剂敏感,预后一般良好。近10年来对MCN的研究日益深入,在发病机理,诊断及治疗上均有新的认识,倾向于将本病作为一种与肾小球肾炎不同的独立的肾小球疾患。名词概念上的发展 MCN是一个以病理形态学为基础的诊断名词。其特点是患者具有肾病表现(旦白尿、浮肿、低旦白血症、高胆固醇血症);肾活检在光镜下缺乏明显的肾小球病变,在电镜下有脏层上皮细胞足突的融合、破坏,细胞肿胀及空泡化。病情缓解后这些改变消失,因此被认为只是旦白尿的后果。这些临床病理特点与Munk 1913年所描述的类脂性肾病即肾病综合征而无明显肾小球病变的概念是十分接近的。长期以来MCN与类脂性肾病被作为同义词使
Micro-lesion nephropathy (referred to as MCN, the same below) is often referred to as lipid-induced nephropathy, nephrotic syndrome is the most common type. About 85% of children with nephrotic syndrome adults accounted for 20 to 30%. In the treatment of corticosteroids and immunosuppressive agents, the prognosis is generally good. The research on MCN has been deepened in the recent 10 years, and there is a new understanding on the pathogenesis, diagnosis and treatment of this disease. It is inclined to treat this disease as an independent glomerular disease which is different from glomerulonephritis. The Conceptual Development of Nouns MCN is a diagnostic term based on pathomorphology. It is characterized by patients with nephropathy (white urine, edema, hypoalbuminemia, hypercholesterolemia); renal biopsy in the light microscope, the lack of significant glomerular lesions under electron microscopy, foot processes of foot processes of epithelial cells Fusion, destruction, cell swelling and vacuolization. After the remission of these changes disappeared, it is considered only the consequences of white urine. These clinicopathological features are very similar to those described by Munk in 1913 for the class of glomerular nephropathy, nephrotic syndrome, with no apparent glomerular lesions. MCN and lipoid nephropathy have long been used as synonyms