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目的:探讨持续静脉应用地尔硫(diltiazem,Dil)治疗不稳定型心绞痛(UA)的临床疗效及可能的作用机制。方法:36例硝酸酯类药物治疗效果不佳的UA患者静脉应用Dil,3～5d后症状消失停用,观察疗效;用药过程中同时观察患者的心率、血压、心电图变化,及有无低血压、心律失常、心功能不全等副作用。结果:36例UA患者心绞痛均完全消失,心电图ST-T改变逐渐恢复,无一例复发,无其他副作用。结论:对于硝酸酯类药物治疗效果不佳的UA,Dil是一种有效的药物。
Objective: To investigate the clinical efficacy and possible mechanism of continuous intravenous diltiazem (Dil) in the treatment of unstable angina pectoris (UA). Methods: Thirty-six patients with UA with poor response to nitrates were treated with Dil intravenously. The symptoms disappeared after 3 to 5 days and the curative effect was observed. The patients’ heart rate, blood pressure, electrocardiogram changes and whether there was hypotension , Arrhythmia, cardiac insufficiency and other side effects. Results: Angina pectoris disappeared completely in 36 cases of UA patients, ST-T changes of electrocardiogram recovered gradually, and no recurrence was found. There was no other side effects. Conclusion: Dil is an effective drug for UA with poor response to nitrates.