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目的探讨生大黄肠道透析联合非生物型人工肝血浆置换(PE)治疗急性肝衰竭的临床疗效。方法采用生大黄取汁200ml行灌肠,联合非生物型人工肝PE治疗急性肝衰竭100例,并与单纯非生物型人工肝PE治疗急性肝衰竭100例对照以比较其疗效。结果生大黄肠道透析联合PE治疗急性肝衰竭总有效率为89.0%,单纯PE治疗总疗效率71.0%,两组比较有明显统计学意义(P<0.05)。生大黄肠道透析联合PE治疗组血氨明显下降,与单纯PE治疗组相比有显著统计学意义(P<0.05)。生大黄肠道透析联合PE治疗组肝功能改善率83例(83.0%),单纯PE治疗组肝功能改善率61例(61.0%),两组比较差异有明显统计学意义(P<0.05)。生大黄肠道透析联合PE治疗组凝血功能明显改善,两组比较具有统计学意义(P<0.05)。并发症发生率生大黄肠道透析联合PE治疗组55例(55.0%),单纯PE治疗组75例(75.0%),两组比较具有统计学意义(P<0.05)。结论生大黄肠道透析联合非生物型人工肝治疗急性肝衰竭具有良好的疗效,值得临床推广。
Objective To investigate the clinical efficacy of rhubarb intestinal dialysis combined with non-biological artificial liver plasma exchange (PE) in the treatment of acute liver failure. Methods 200 ml of rhubarb juice was used for the treatment of 100 cases of acute hepatic failure by combination of non-bioartificial artificial liver enema, and compared with 100 cases of acute non-bioartificial hepatic failure. Results The total effective rate of rhubarb intestinal dialysis combined with PE in treatment of acute liver failure was 89.0%, and the total effective rate of simple PE treatment was 71.0%. There was significant difference between the two groups (P <0.05). The blood ammonia in rhubarb intestinal dialysis combined with PE treatment group decreased significantly, compared with the simple PE treatment group (P <0.05). There were 83 cases (83.0%) of hepatic function improvement in rhubarb intestinal dialysis combined with PE treatment group, and 61 cases (61.0%) of liver functional improvement in simple PE treatment group. There was significant difference between the two groups (P <0.05). The coagulation function of rhubarb dialysis combined with PE treatment group was significantly improved, the two groups had statistically significant (P <0.05). The incidence of complications was 55 cases (55.0%) in rhubarb intestinal dialysis combined with PE treatment group and 75 cases (75.0%) in simple PE treatment group, the two groups had statistical significance (P <0.05). Conclusion Rhubarb intestinal dialysis combined with non-biological artificial liver treatment of acute liver failure has a good effect, it is worth clinical promotion.